Introduction – Company Background
GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.
With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.
With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.
From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.
At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.
By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.
Core Strengths in Insole Manufacturing
At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.
Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.
We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.
With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.
Customization & OEM/ODM Flexibility
GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.
Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.
With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.
Quality Assurance & Certifications
Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.
We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.
Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.
ESG-Oriented Sustainable Production
At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.
To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.
We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.
Let’s Build Your Next Insole Success Together
Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.
From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.
Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.
🔗 Learn more or get in touch:
🌐 Website: https://www.deryou-tw.com/
📧 Email: shela.a9119@msa.hinet.net
📘 Facebook: facebook.com/deryou.tw
📷 Instagram: instagram.com/deryou.tw
Vietnam custom neck pillow ODM
Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.
With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Pillow OEM for wellness brands Indonesia
Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.
We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Taiwan sustainable material ODM solutions
At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.ODM pillow for sleep brands China
📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Taiwan insole ODM full-service provider factory
Scientists have developed a groundbreaking method to link genetics with the activity of anaerobic microbes, revealing key insights into microbial communities deep below Earth’s surface. This approach, showcasing a dominant bacterium in Death Valley’s aquifer, opens new avenues for understanding microbial roles in global processes. A team of scientists led by researchers at Bigelow Laboratory for Ocean Sciences have developed an innovative method to link the genetics and function of individual microbes living without oxygen deep below Earth’s surface. Measuring both of these attributes — and, more importantly, linking them together — has long been a challenge in microbiology but is critical for understanding the role of microbial communities in global processes like the carbon cycle. The new approach, developed at Bigelow Laboratory’s Single Cell Genomics Center, enabled researchers to discover that one species of sulfate-consuming bacterium was not only the most abundant but also the most active organism in a groundwater aquifer beneath Death Valley, almost half a mile below the surface. The findings, published in the Proceedings of the National Academy of Sciences, show how this method can be a powerful tool for measuring how active different organisms are in these extreme environments. Insights into Microbial Community Dynamics “Previously, we had to assume that all cells were operating at the same rate, but now we can see that there is a wide range of activity levels between individual members of the microbial communities,” said Research Scientist and lead author on the paper Melody Lindsay. “That helps us understand what these microbial communities are capable of and how that might influence global biogeochemical cycles.” The Desert Research Institute team extracting samples from the bore hole at Death Valley. Credit: Duane Moser, Desert Research Institute The recent study is a part of a larger project linking the genetic code of microbes — the blueprint of what they’re capable of — to what they’re actually doing at any given moment. Methodological Advances Funded by NSF’s EPSCoR program, the “Genomes to Phenomes” project is a joint venture between Bigelow Laboratory, the Desert Research Institute, and the University of New Hampshire. It leverages recent advances in single-cell genetic sequencing with a creative approach applying flow cytometry to estimate the rates of processes, such as respiration, happening within those cells. Flow cytometry, a method for analyzing individual environmental microbes that was adapted at Bigelow Laboratory from the biomedical sciences, allowed the researchers to quickly sort out living microbes in the aquifer water samples. Those microbes were stained with a specially designed compound that lights up under the flow cytometry laser when certain chemical reactions are happening within the cell. The relationship between how much the cell fluoresces under the laser and the rate of those reactions was worked out experimentally with lab-grown cultures of cells by student interns at Bigelow Laboratory and then applied to the Death Valley samples. Once the active cells were measured and isolated, the team sequenced their individual genomes. The researchers also used meta-transcriptomics, a method for determining which genes are being actively expressed, and radioisotope tracers, a more traditional method for measuring activity within a microbial community. This was done both to “double check” their results and to get even more information on the links between what these microbes are genetically capable of and what they’re actually doing. The Single Cell Genomics Center is the only analytical facility in the world offering this new technique to researchers. “This study was an exciting opportunity for our research team and the SCGC to help improve our understanding of the immense, enigmatic microbial ecosystems underground,” said Bigelow Laboratory Senior Research Scientist Ramunas Stepanauskas, the director of SCGC and principal investigator of the project. This new study builds on the first demonstration of this approach for quantifying the activity of individual cells. In late 2022, the team published findings on microbes in seawater, showing that a small fraction of microorganisms is responsible for consuming most of the oxygen in the ocean. With this new paper, the team is expanding that method to show it can be used in low biomass environments with microbes that don’t rely on oxygen. In the samples drawn from the subsurface aquifer in California, for example, the scientists estimated that there were hundreds of cells per milliliter of water, compared to millions of cells in a typical milliliter of surface water. “We started out with oxygen-respiring organisms in the ocean because they’re a little more active, a little easier to sort, and easier to grow in the lab,” Lindsay said. “But aerobic respiration is just one process that is possible in microbiology, so we wanted to branch out beyond that.” Expanding the Scope of Microbial Research The results confirmed that the bacterium Candidatus Desulforudis audaxviator was not only the most abundant microbe in this environment, but also the most active, reducing sulfate for energy. The overall activity rates the team measured were low compared to the seawater samples from the previous study, but there were large differences between how active individual microbes were. The research team is now working to apply their method to measure other anaerobic reactions, such as nitrate reduction, and to new environments, including sediments along Maine’s coast. A related project funded by NASA is also enabling Lindsay and her colleagues to test the method in the deep subsurface below the ocean. “Right now, we’re getting all of these point measurements around the world, and they do help us better understand what microbes are up to, but we need to scale it up,” Lindsay said. “So, we’re thinking about how to apply this method in new places, even potentially on other planets, in expanded ways.” Reference: “Species-resolved, single-cell respiration rates reveal dominance of sulfate reduction in a deep continental subsurface ecosystem” by Melody R. Lindsay, Timothy D’Angelo, Jacob H. Munson-McGee, Alireza Saidi-Mehrabad, Molly Devlin, Julia McGonigle, Elizabeth Goodell, Melissa Herring, Laura C. Lubelczyk, Corianna Mascena, Julia M. Brown, Greg Gavelis, Jiarui Liu, D. J. Yousavich, Scott D. Hamilton-Brehm, Brian P. Hedlund, Susan Lang, Tina Treude, Nicole J. Poulton, Ramunas Stepanauskas, Duane P. Moser, David Emerson and Beth N. Orcutt, 4 April 2024, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2309636121
The study also shed light on how photosynthesis adapted to the rise of oxygen. Back to the Future of Photosynthesis Rubisco, the central biocatalyst in photosynthesis, is the most prevalent enzyme on the planet. A group of Max Planck Institute researchers has uncovered one of the key early photosynthesis adaptations by reconstructing billion-year-old enzymes. Their findings not only shed light on how modern photosynthesis evolved, but also provide new impulses for enhancing it. Today’s life is entirely dependent on photosynthetic organisms such as plants and algae that capture and convert CO2. An enzyme known as Rubisco, which absorbs more than 400 billion tons of CO2 annually, is at the heart of these processes. Rubisco is produced in astounding quantities by living things today; its mass on Earth exceeds that of all humans combined. Rubisco has to continually adapt to shifting environmental circumstances in order to play such a major role in the global carbon cycle. A team from the Max Planck Institute for Terrestrial Microbiology in Marburg, Germany, in partnership with the University of Singapore, has now successfully resurrected and studied billion-year-old enzymes in the lab using a combination of computational and synthetic techniques. The researchers discovered that in this process, which they refer to as “molecular paleontology,” a completely new component prepared photosynthesis to adapt to increased oxygen levels rather than direct mutations in the active center. Cryo-electron microscope image of two Rubisco complexes interacting with each other. If a subunit essential for solubility is missing, individual enzyme complexes can interact with each other in this way and form thread-like structures, so-called fibrils. Under normal conditions, however, Rubisco does not form such fibrils. Credit: MPI f. Terrestrial Microbiology/ L. Schulz Rubisco’s Early Confusion Rubisco is ancient: it emerged approximately four billion years ago in primordial metabolism prior to the presence of oxygen on earth. However, with the invention of oxygen-producing photosynthesis and the rise of oxygen in the atmosphere, the enzyme started catalyzing an undesired reaction, in which it mistakes O2 for CO2 and produces metabolites that are toxic to the cell. This confused substrate scope still scars Rubiscos to date and limits photosynthetic efficiency. Even though Rubiscos that evolved in oxygen-containing environments became more specific for CO2 over time, none of them could get completely rid of the oxygen-capturing reaction. The molecular determinants of increased CO2 specificity in Rubisco remain largely unknown. However, they are of great interest to researchers aiming to improve photosynthesis. Interestingly, those Rubiscos that show increased CO2 specificity recruited a novel protein component of unknown function. This component was suspected to be involved in increasing CO2 specificity, however, the true reason for its emergence remained difficult to determine because it already evolved billions of years ago. Studying Evolution by Resurrecting Ancient Proteins in the Lab To understand this key event in the evolution of more specific Rubiscos, collaborators at the Max Planck Institute for Terrestrial Microbiology in Marburg and Nanyang Technological University in Singapore used a statistical algorithm to recreate forms of Rubiscos that existed billions of years ago, before oxygen levels began to rise. The team led by Max Planck researchers Tobias Erb and Georg Hochberg resurrected these ancient proteins in the lab to study their properties. In particular, the scientists wondered whether Rubisco’s new component had anything to do with the evolution of higher specificity. The answer was surprising, as doctoral researcher Luca Schulz explains: “We expected the new component to somehow directly exclude oxygen from Rubisco catalytic center. That is not what happened. Instead, this new subunit seems to act as a modulator for evolution: recruitment of the subunit changed the effect that subsequent mutations had on Rubisco’s catalytic subunit. Previously inconsequential mutations suddenly had a huge effect on specificity when this new component was present. It seems that having this new subunit completely changed Rubisco’s evolutionary potential.” An Enzyme’s Addiction to Its New Subunit This function as an “evolutionary modulator” also explains another mysterious aspect of the new protein component: Rubiscos that incorporated it are completely dependent on it, even though other forms of Rubisco can function perfectly well without it. The same modulating effect explains why: When bound to this small protein component, Rubisco becomes tolerant to mutations that would otherwise be catastrophically detrimental. With the accumulation of such mutations, Rubisco effectively became addicted to its new subunit. Altogether, the findings finally explain the reason why Rubisco kept this new protein component around ever since it encountered it. Max Planck Research Group Leader Georg Hochberg explains: “The fact that this connection was not understood until now highlights the importance of evolutionary analysis for understanding the biochemistry that drives life around us. The history of biomolecules like Rubisco can teach us so much about why they are the way they are today. And there are still so many biochemical phenomena whose evolutionary history we really have no idea about. So it’s a very exciting time to be an evolutionary biochemist: almost the entire molecular history of the cell is still waiting to be discovered.” Scientific journeys back in time can provide invaluable insights for the future The study also has important implications for how photosynthesis might be improved, says Max Planck Director Tobias Erb: “Our research taught us that traditional attempts to improve Rubisco might have been looking in the wrong place: for years, research focused solely on changing amino acids in Rubisco itself to improve it. Our work now suggests that adding entirely new protein components to the enzyme could be more productive and may open otherwise impossible evolutionary paths. This is uncharted land for enzyme engineering.” Reference: “Evolution of increased complexity and specificity at the dawn of form I Rubiscos” by Luca Schulz, Zhijun Guo, Jan Zarzycki, Wieland Steinchen, Jan M. Schuller, Thomas Heimerl, Simone Prinz, Oliver Mueller-Cajar, Tobias J. Erb and Georg K. A. Hochberg, 13 October 2022, Science. DOI: 10.1126/science.abq1416
Anaerobic bacteria, which thrived in oxygen-free environments long before oxygen-dependent life forms, are vital for both human health and the ecosystem, influencing everything from gut health to disease. The AnoxyGen project led by Christian Hertweck aims to explore these bacteria’s untapped biosynthetic potentials to discover new compounds, improving medical, ecological, and biotechnological understanding and applications. Credit: SciTechDaily The AnoxyGen project, led by Christian Hertweck and funded by the ERC Advanced Grant, explores the potential of anaerobic bacteria in biotechnology, medicine, and ecology, aiming to discover new bioactive compounds. The earth was populated with numerous organisms long before photosynthesis brought free oxygen into the world. Since oxygen was toxic to them, they developed completely different metabolic pathways than oxygen-dependent lifeforms such as humans, animals, and plants. Anaerobic bacteria have survived the ages in special, oxygen-free niches, some of them very close to us: as an essential part of the intestinal microbiome, where they are of enormous importance for the well-being of the organism. However, certain anaerobes can also trigger life-threatening diseases such as tetanus or botulism. These bacteria therefore have a considerable influence on the quality of life on earth and occupy a key position in the environment. Their special metabolism also makes them sought-after tools in biotechnology. Scanning electron micrograph of Ruminiclostridium cellulolyticum. Christian Hertweck and his team discovered closthioamide in the cellulose-degrading anaerobic bacterium – the first secondary natural compound in this group of organisms. Credit: S. Nietzsche/EMZ Jena Unleashing Anaerobic Potential Through the AnoxyGen Project Christian Hertweck’s “AnoxyGen” project aims to unlock the immense, previously untapped biosynthetic potential of anaerobes. Despite their genome-encoded ability to form novel compounds, most of these biosynthetic genes are inactive in the laboratory, so the products have so far remained undiscovered. Hertweck and his team now want to change this. Using newly developed molecular and synthetic biology tools, the researchers want to decode and harness the unknown metabolic pathways of these bacteria. The project encompasses several areas of work in which a powerful expression system is used to identify and modify new active compounds. This will also enable the team to produce and research the toxins and virulence factors of pathogenic anaerobes without having to cultivate large quantities of the pathogens themselves. Scanning electron micrograph of anaerobic bacteria of the species Clostridium puniceum on a potato slice. Clostrubins were discovered on this model system by a team led by Christian Hertweck. Clostrubins have an antibiotic effect and protect the bacteria from oxygen while they infect the potato tuber and use it as a food source. Credit: Gulimila Shabuer / Leibniz-HKI and EMZ Jena Recognition and Future Prospects of the AnoxyGen Project “With this project, we want to provide novel methods and tools for the scientific community. We hope that ‘AnoxyGen’ will be of great benefit, particularly for medicine, but also for ecology and biotechnology,” explains Hertweck. “Anaerobic bacteria are still under-researched, but their metabolic processes offer great potential for the discovery of new active compounds. We can also gain new insights into their role as pathogens.” Prof. Dr. Christian Hertweck, head of the Department of Biomolecular Chemistry at the Leibniz-HKI and professor of Natural Product Chemistry at the Friedrich Schiller University Jena, has been awarded one of the prestigious ERC Advanced Grants by the European Research Council. Credit: Anna Schroll/Leibniz-HKI Hertweck, who has already been awarded the Gottfried Wilhelm Leibniz Prize and the Ernst Jung Prize for Medicine for his great scientific creativity in identifying new active compounds from neglected microorganisms, is also strengthening the Balance of the Microverse Cluster of Excellence, which studies the formation and balance of microbial communities, with this project. Anaerobic bacteria have so far played a subordinate role there, partly because they were difficult to access methodologically. The researcher now wants to close this gap. Hannah Büttner from Christian Hertwecks team is experimenting with oxygen-sensitive bacteria of the genus Clostridium in a protected atmosphere in a so-called anaerobic box. Credit: Anna Schroll/Leibniz-HKI The ERC Advanced Grant, one of the most prestigious grants of the European Union, recognizes the excellence and innovation of top researchers. Christian Hertweck’s “AnoxyGen” project was selected due to its great prospects for expanding our understanding of microbial biosynthesis and developing new biotechnological applications. With comfortable financial resources, the researcher and his interdisciplinary team will be tackling this topic over the next five years.
DVDV1551RTWW78V
Taiwan graphene material ODM factory 》committed to ESG, comfort, and your brand is successChina flexible graphene product manufacturing 》where form meets function, every step of the wayInnovative insole ODM solutions in Vietnam 》your reliable OEM/ODM partner for long-term collaboration